PAPER 2 · QUESTION 1 STYLE · MODULAR UNIT 2

Living on the roof of the world

312 words over 29 numbered lines, then 6 parts worth 12 marks (Modular Unit 2 (4WBI2) style, 12–13 marks). Read the article, answer each part, then open its mark scheme and set your mark.

4WBI212 marksabout 14 minutes

Article

Illustrative article written for Scholar Lab, not a Pearson text. The biology is real; the studies, people and figures are invented or rounded for practice.

Living on the roof of the world

At the top of a high mountain, the air contains the same proportion of

oxygen as the air at sea level, but the air is much less dense. Each

breath therefore contains fewer oxygen molecules. Climbers who arrive

quickly from sea level often feel breathless and tired, and some

develop headaches and sickness.

In the lungs, oxygen diffuses from the air in the alveoli into the

blood in the capillaries. At high altitude the concentration of oxygen

in the alveoli is lower, so the concentration gradient is less steep

and less oxygen enters the blood each minute. Muscle cells then

receive less oxygen for aerobic respiration.

Oxygen is carried by red blood cells. These cells have a biconcave

disc shape, no nucleus, and are packed with haemoglobin, which

combines with oxygen in the lungs and releases it in the tissues.

Within a few weeks at high altitude, the body makes more red blood

cells, and the concentration of haemoglobin in the blood rises.

Figure 1 shows illustrative blood tests from three groups of adults:

people living at sea level, the same people after three weeks at a

mountain research station, and people whose families have lived at

high altitude for many generations.

Having more red blood cells is not always helpful. The blood becomes

thicker, so the heart has to work harder to pump it around the body,

and blood clots may form more easily. Some groups of people who have

lived at high altitude for thousands of years have a different

solution: they breathe faster and deeper, and have wider blood

vessels, but have a similar number of red blood cells to people living

at sea level.

Some athletes now train at high altitude for several weeks before

important races held at sea level, hoping that the extra red blood

cells will still be there on the day of the race.

Figure 1 Blood test results from three groups of adults

GroupRed blood cells / millions per mm³Haemoglobin / g per 100 cm³
Sea-level residents5.014.5
Same people after 3 weeks at altitude5.516.0
Long-term high-altitude residents6.017.5
Illustrative mean values.

Read the article and study the figure. Use the information in the article and your own knowledge to answer the questions. The lines in brackets show where to look; select them to highlight the text.

Use the information in the article and your own knowledge to answer the questions. The lines in brackets show you where to look; select them to highlight the text.

(a)

State what is meant by the term diffusion.

(1)
(b)

Describe two ways in which red blood cells are adapted to carry oxygen.

(2)
(c)

Explain why climbers who arrive quickly at high altitude feel tired.

(3)
(d)

Use Figure 1 to calculate the percentage increase in haemoglobin concentration after three weeks at altitude. Give your answer to one decimal place.

(2)
(e)

Explain why having a very large number of red blood cells may be harmful.

(2)
(f)

Suggest how training at high altitude could help an athlete in a race held at sea level.

(2)

Total for this question: 12 marks

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